张翱

人物履历

1988 年 9 月至 1992 年 7 月，就读于四川师范学院（现西华师范大学）化学系，获学士学位； 1992 年 9 月至 1995 年 7 月，就读于南开大学元素有机化学研究所，获硕士学位； 1997 年 10 月至 2000 年 10 月，中科院上海有机化学研究所，获博士学位，导师为姜标研究员。 1995 年 7 至 1997 年 9 月，在中科院上海有机化学研究所工作，任研究实习员。 2001 年 2 月至 2002 年 3 月，在美国乔治敦大学（ Georgetown University ） 医药中心作博士后访问学者； 2002 年 4 月至 2006 年 2 月，在美国哈佛大学（ Harvard University ）医学院工作，任哈佛医学院 Instructor ， McLean Hospital 药物化学研究室 Assistant Director ， 美国化学会东北分会会刊《 The Nucleus 》副编辑； 2006 年至今在中国科学院上海药物研究所工作，获中科院 " 百人计划 " 择优支持。

研究方向

张翱研究组主要从事创新药物研发及相关基础研究，尤其是靶向G-蛋白偶联受体（GPCR）和酪氨酸激酶（RTK）新型小分子药物的设计与合成研究。主要是通过发展新颖简捷合成方法实现类药性优势骨架的高效合成，以及基于活性天然产物类药性骨架进行多样性合成和衍生化，结合现代药物结构优化策略，探索药物的结构与活性、结构与靶向性、结构与成药性等规律，进而开发具有抗神经退行性疾病和抗肿瘤活性的新型药物。研究组目前正在进行的研究课题主要有： 【1】具有抗肿瘤活性的类药性天然产物的合成及基于成药性的结构优化； 【2】靶向酪氨酸激酶或DNG修复等特异性或多靶性抑制剂抗肿瘤药物的设计与合成； 【3】靶向G-蛋白偶联受体小分子药物的设计及抗神经退行性疾病活性研究。

专家类别

研究员；百人计划；国家杰出青年

职务

中科院上海药物所研究员、博士生导师、研究组长

获奖及荣誉

2004年获哈佛医学院McLean Hospital年度最高学术奖-A LFRED POPE AWARD；同年还获得哈佛医学院 McLean Hospital - ADAM CORNEEL YOUNG INVESTIGATOR AWARD；2010年获中科院“百人计划”终期评估优秀奖；2011年获国家杰出青年基金。

代表论著

1、SELECTED PUBLICATIONS Chengtang Du, Fulong Li, Xuefeng Zhang, Wenxiang Hu, Qizheng Yao, Ao Zhang. Lewis Acid-Catalyzed Cyclization of Glycals/2-deoxy-D-ribose with Aryl Amines: Additional Findings on Product Structure and Reaction Diastereoselectivity. J. Org. Chem Jun Sun, Xuefeng Zhang, Fulong Li, Chunyong Ding, Wenjuan Wu, Ao Zhang. Base-promoted reaction of methyl 4,6-O-benzylidene-3-deoxy-hexopyranosid-2-ulose and various arylamines Tetrahedron Lett. Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors. Org. Biomol. Chem Hai Zhang, Na Ye, Shanglin Zhou, Lin Guo, Longtai Zheng, Zhili Liu, Bo Gao, Xuechu Zhen, and Ao Zhang: Identification of N-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson's Agent Possessing a Dopamine D2 and Serotonin 5-HT1A Dual-Agonist Profile. J. Med. Chem Ailing Zhao, Xin Gao, Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Meiyu Geng, Ao Zhang: Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold. Bioorg. Med. Chem Zhiqing Liu, Qingzhang Zhu, Fuying Li, Lina Zhang, Ying Leng, Ao Zhang: N-(5-Substituted Thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) Propanamides as Glucokinase Activators. MedChemComm Fulong Li, Chunyong Ding, Meining Wang, Qizheng Yao, Ao Zhang: InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones. J. Org. Chem Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng, Ao Zhang: Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri- substituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)- 5-(3-nitrobenzylamino)- 7- (trifluoromethyl)quinoline as a novel anticancer agent. J. Med. Chem Na Ye, QianQian Wu, Liyuan Zhu, Longtai Zheng, Bo Gao, Xuechu Zhen, Ao Zhang: Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands. Bioorg. Med. Chem. Jing Zhang, Kui Wu, Meining Wang, Jianqin Jiang, Ao Zhang: FeCl3.6H2O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines: substrate extension and product utilization. Tetrahedron Tu, S.; Ding, C.; Hu, W.; Li, F.; Yao, Q.; Zhang A. Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence. Mol Divers Fuying Li, Qingzhang Zhu, Yi Zhang, Ying Feng, Ying Leng, Ao Zhang: Design, synthesis and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators. Bioorg. Med. Chem Chunyong Ding, Shanghui Tu, Qizheng Yao, Fulong Li, Yuanxiang Wang, Wenxiang Hu, Ao Zhang: One-Pot Three-step Synthesis of Naphtho [2,3-a]carbazole-5,13-diones Using Tandem Radical Alkylation-Cyclization -Aromatization Reaction Sequence. Adv Syn Catal Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang: Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem Yi Zhang, Zhaobin Han, Fuying Li, Kuiling Ding and Ao Zhang: Highly enantioselective hydrogenation of a-aryl-b-substituted acrylic acids catalyzed by Ir-SpinPHOX. Chem. Commun Jing Zhang, Ao Zhang: Unprecedented FeCl3·6H2O-Promoted Skeleton-Rearrangement of 1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a New Strategy for the Synthesis of C-1 Quaternary Tetrahydroisoquinolines. Chem. Eur. J Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: [6,7]-Heterocycle-Fused 14-Hydroxymorphinan Derivatives: Design, Synthesis, and Opioid Receptor Activity. ChemMedChem Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: Synthesis and SAR study of opioid receptor ligands: momo- and bis-indolomorphinans. Chem Biol Drug De Chunyong Ding, Shanghui Tu, Fuying Li, Yuanxiang Wang, Qizheng Yao, Wenxiang Hu, Hua Xie, Linghua Meng, Ao Zhang: Synthesis Study on Marmycin A: Preparation of the C3’-Desmethyl Analogues. J. Org. Chem Yuanxiang Wang, Ao Zhang: Expeditious synthesis of 2,3-dihydro-2-alkoxy-3-methylenebenzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides. Tetrahedron Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Ao Zhang: Synthesis and opioid receptor activity of indolopropellanes. Bioorg. Med. Chem. Lett Jing Zhang, Hai Zhang, Wenxian Cai, Leiping Yu, Xuechu Zhen, Ao Zhang: “Click” D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity. Bioorg. Med. Chem Xue-Qin Chen, Jing Zhang, John L. Neumeyer, Guo-Zhang Jin, Guo-Yuan Hu, Ao Zhang, Xuechu Zhen: Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoS One Yu-Jun Wang, Yi-Min Tao, Fu-Ying Li, Yu-Hua Wang, Xue-Jun Xu, Jie Chen, Ying-Lin Cao, Zhi-Qiang Chi, John L. Neumeyer, Ao Zhang, and Jing-Gen Liu: Pharmacological Characterization of ATPM, a Novel Mixed Agonist and µ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J. Pharm. Exp. Ther Zhili Li, Jing Zhang, Ao Zhang: Design of multivalent ligand targeting g-protein-coupled receptors.Curr Pharm Des Jing Zhang, Bing Xiong, Xuechu Zhen, Ao Zhang: Dopamine D1 receptor ligands: Where are we now and where are we going, Med. Res. Rev